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Devil Rooms. Angel Rooms. I wrote this guide in order to help people find these Devil rooms more easily so you can give me your life, and I hope you will be somewhat enlightened before you finish! I will also cover Angel rooms, which can be much more annoying. A Devil Room spawned on the previous floor. Teleporting to it beforehand via red chests or the Joker doesn't count, but you don't have to actually enter it.

You have not done ANY deals with the devil. The funny thing is that there are two "You Feel Blessed! This decision overrides all other probability checks done by the game. Spoiler tips: Having Key Piece 1 or 2 increases your chance of finding an Angel Room, which can be combined with Rosary Bead nicely. Thanks for reading this, and I hope this guide will be helpful with your runs of the Binding of Isaac: Feel free to point out any errors! Good luck, and have fun!

Shelby-Kun 22 Apr, Avoumen 17 Feb, 4: Updated with Afterbith and new information. I'm going to update it if it's trending, along with some extra info for Afterbirth. Guppy's Hair Ball.

Devil Room (Afterbirth+ Item Pool)

Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies. Guppy's Tail. Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups. Headless Baby. Familiar that follows Isaac, leaving blood creep on the ground.

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Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room. Increases damage and increases the chance for a Devil or Angel Room to appear. Sacrificial Dagger.

Devil Room

A familiar that follows Isaac around shooting blood tears. Whore of Babylon. Increases damage and speed whenever Isaac has half a red heart or less one red heart for Eve , ignoring any soul or black hearts. Increases damage and speed, removes all red heart containers , grants six black hearts , and adds a chance to shoot fear tears. Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.

Death's Touch. Increases Damage by 1. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only. Judas' Shadow. Adds an extra life; upon death , it respawns Isaac as Black Judas with only two black hearts. Lil Brimstone. A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.

Lord of the Pit. Mom's Knife. Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again. Empty Vessel. While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds.

If Isaac gains any red hearts, these benefits will disappear. Spawns a familiar that follows Isaac around and fires spectral tears. Has a chance of spawning a soul heart or black heart when taking damage.

Enemies have a chance to drop a Half Red Heart after being killed. Guppy's Collar. Guppy's Hair Ball.


  • Devil Room (Item Pool).
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  • Devil Room (Afterbirth Item Pool) - Binding of Isaac: Rebirth Wiki.
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  • Devil Room (Afterbirth Item Pool).

Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle.

Devil Room - Binding of Isaac: Rebirth Wiki

Grows bigger by killing enemies. Guppy's Tail. Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups. Headless Baby. Familiar that follows Isaac, leaving blood creep on the ground. Missing Page 2. Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.

Multidimensional Baby. Spawns a familiar that will follow Isaac's movements on a 2. Tears that pass through the baby will be doubled and increase in speed. My Shadow. Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much. Increases damage and increases the chance for a Devil or Angel Room to appear.

Sacrificial Dagger. A familiar that follows Isaac around shooting blood tears. Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.

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Whore of Babylon. Increases damage and speed whenever Isaac has half a red heart or less one red heart for Eve , ignoring any soul or black hearts. Increases damage and speed, removes all red heart containers , grants six black hearts , and adds a chance to shoot fear tears. Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period. Death's Touch. Increases Damage by 1. Grants piercing tears.