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The company has said 32 million women suffer from the condition that their drug addresses, but only about 7 percent — or 2.

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Some said Imvexxy had a role to play. Many women are worried about taking estrogen because of earlier studies that showed taking oral hormones carried serious risks. The lower dose may allay those concerns, although other vaginal estradiol products have also shown that they do not significantly increase estrogen levels throughout the body.

All of the products, including Imvexxy, carry an F. Streicher said. TherapeuticsMD paid her to lead one focus group for women that discussed sexual health and did not mention Imvexxy, she said.

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Some companies are using a playful marketing approach, signaling the issue is not as taboo as it once was. Some of these products may soon come down in price. In October , a generic of Vagifem, called Yuvafem , entered the market at a slightly reduced list price. Then, in July of last year, Teva Pharmaceuticals began selling a second generic at an even cheaper price.

If more generic manufacturers enter the market, the price could tumble more and Vagifem could become an inexpensive drug like many cholesterol or blood pressure medicines. The same could become true for Estrace cream, which lost its patent protection at the end of last year and now has several generic competitors. With two generics for Vagifem now available, the drug companies are most likely negotiating big discounts with insurers, meaning patients with coverage may see their costs drop. Elizabeth Traynor, an illustrator in Guntersville, Alabama, had tried virtually every estradiol product and balked at the prices, frequently doing without.

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Estradiol has been around for so long that it has survived several rounds of debate over high prices. In , a Senate inquiry found that the drug maker Schering, now part of Merck, had marked up estradiol — which comes in many forms — by more than 7, percent over the cost of materials. In an echo of modern-day industry talking points , a Schering executive was quoted in an article in The New York Times , saying the high prices were necessary to finance new medical research.

June 15, A version of this article appears in print on , on Page B1 of the New York edition with the headline: Patients Eagerly Awaited a Generic Drug. Then They Saw the Price. Open in the app. Discontinue estrogen if hypercalcemia, sudden partial or complete loss of vision, hypertriglyceridemia, or cholestatic jaundice occurs.

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Patients dependent on thyroid hormone replacement therapy should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable range. Endometriosis may be exacerbated in women treated post-hysterectomy with estrogen-alone therapy. The addition of progestins should be considered in these patients. The most common side effects include: The warnings, precautions, and adverse reactions associated with oral estrogen treatment should be taken into account. For more information, please follow the link to see Full Prescribing Information, including Boxed Warning.

Teva Pharmaceutical Industries Ltd. TEVA is a leading global pharmaceutical company that delivers high-quality, patient-centric healthcare solutions used by approximately million patients in over 60 markets every day.

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In specialty medicines, Teva has the world-leading innovative treatment for multiple sclerosis as well as late-stage development programs for other disorders of the central nervous system, including movement disorders, migraine, pain and neurodegenerative conditions, as well as a broad portfolio of respiratory products. Teva is leveraging its generics and specialty capabilities in order to seek new ways of addressing unmet patient needs by combining drug development with devices, services and technologies.

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